Dr. Prawej Ansari, Assistant Professor, Department of Pharmacy presented his research findings in 69th International Congress and Annual Meetings of the Society for Medicinal Plants and Natural Product Research, Bonn, Germany
Around 32 research scientists from all over the world submitted their abstract in 69th International Congress and Annual Meetings of the Society for Medicinal Plants and Natural Product Research in young research workshop for oral presentation, from which 13 got selected. Among them, Dr. Ansari received 9th rank. He was the only young research scientist who got selected to present his research findings in young research workshop from Bangladesh. The title of his presentation was: “Antidiabetic and insulinotropic properties of bark of Heritiera fomes: inhibits starch digestion, protein glycation, DPP-IV activity, and glucose absorption in gut”.
The research findings presented in the conference was performed in the Pharmacology laboratory of Department of Pharmacy, IUB in collaboration with Prof Peter R. Flatt, Research Director, School of Biomedical Sciences, Diabetes research Group, Ulster University, UK. The research group, IUB-PL was the leading group which actively contributed to the animal section of the experiments while DRG played a role in the in vitro section of the experiments. The present study investigated the effects of ethanol extract of H. fomes (EEHF) on insulin release from clonal pancreatic β-cells and mouse islets and other in vitro system and glucose homeostasis in type 2 diabetic rats. EEHF, significantly stimulated insulin release in concentration-dependent manner from BRIN-BD11 cells and isolated mouse islets with stimulatory effects equivalent in magnitude to 1µM GLP-1. Insulinotropic effects of H. fomes (200µg/ml) on BRIN-BD11 cells were partly inhibited by verapamil, diazoxide and calcium free conditions showing importance of ion channels and Ca2+ in mechanism of action. Secretion was further potentiated by activation of augmentation pathways revealed using IBMX, tolbutamide and KCl. The extract signiﬁcantly inhibited postprandial hyperglycaemia after sucrose load and inversely increased unabsorbed sucrose content throughout the gut, suppressed the glucose absorption during in situ gut perfusion and improved gut motility. This investigation hypothesized insulin release is the mechanism of action to control diabetes indeed and reassures to carry on to establish the plant for diabetes treatment.
The recent outcomes is not only the achievement for the department of Pharmacy, but it also represented Independent University, Bangladesh in the world via this conference. This conference paper mainly focused on metabolic syndrome: Diabetes, which is one of the 7th leading cause of death in the world. All the efforts of members (Dr. Prawej Ansari, Assistant Professor and Prof. JMA Hannan, Dean, Department of Pharmacy, SPPH) of research group made it possible to achieve a highly effective research findings which can contribute to the current scenario of the world.