High Impact Factor Journal Publication of IUB Pharmacology Laboratory (IUB-PL) of the Pharmacy Department in Collaboration with the Diabetes Research Group, Ulster University (UK)
IUB Pharmacology Laboratory (IUB-PL), a research group in the Department of Pharmacy, School of Pharmacy and public health have published a journal paper on the 11th of June, 2021, titled “Identification of Multiple Pancreatic and Extra-Pancreatic Pathways Underlying the Glucose-Lowering Actions of Acacia arabica Bark in Type-2 Diabetes and Isolation of Active Phytoconstituents”, in the journal of “Plants”, a peer-reviewed scientific journal published by the Multidisciplinary Digital Publishing Institute, Basel, Switzerland. According to the Journal Citation Report, it is a Q1 rank journal with an impact factor of 4.00. This year the Journal “Plants” celebrated its 10th anniversary.
In this project, IUB-PL collaborated with Prof. Peter R. Flatt, Research Director of School of Biomedical Sciences, Ulster University, UK, and Dr. Yasser H.A. Abdel-Wahab, Reader at School of Biomedical sciences, Diabetes Research Group, Ulster University, UK. This study elucidated the antidiabetic actions of A. arabica bark together with the isolation of bioactive molecules. The research teams from IUB-PL performed the in vivo studies on high fat fed animals for the project whereas, DRG was the leading group in this project specially on the experiments including in vitro and, isolation and characterization of phytomolecules. The recent findings reported that Hot-water extract of A. arabica (HWAA) increases insulin release from clonal β-cells and mouse islets by 1.3–6.8-fold and 1.6–3.2-fold, respectively. Diazoxide, verapamil and calcium-free conditions decrease insulin-secretory activity by 30–42%. In contrast, isobutylmethylxanthine (IBMX), tolbutamide and 30 mM KCl potentiate the insulin-secretory effects. The mechanism of actions of HWAA involves membrane depolarisation and elevation of intracellular Ca2+ together with an increase in glucose uptake by 3T3-L1 adipocytes. Acute HWAA administration (250 mg/5 mL/kg) enhances glucose tolerance and plasma insulin in HFF obese rats. The results indicate that HWAA has the potential to treat type 2 diabetes as a source of antidiabetic agents, including quercetin and kaempferol. This is very significant achievement for the department of Pharmacy of Independent University, Bangladesh.
The research article involved laboratory-based work by considering the current scenario of Diabetes in the world. The endeavour was made possible due to the dedication of members of the research group, Dr. Prawej Ansari, Assistant Professor and Prof. JMA Hannan, Dean, Department of Pharmacy, SPPH as their consistent efforts to create world-class scientific research findings from IUB. This prestigious publication is an evidence to the enthusiastic commitment of the IUB-PL as well as the Department of Pharmacy towards high-quality research and contributing towards health sciences in some extend.