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Dr Prawej Ansari published article in high impact journal in collaboration with Ulster University, UK, and University of Minnesota, Austin, USA


Dr. Prawej Ansari, Assistant Professor, Department of Pharmacy, School of Pharmacy and Public Health has published a journal paper on the 23rd of November 2021, titled “Exploiting the Metabolism of the Gut Microbiome as a Vehicle for Targeted Drug Delivery to the Colon” in the journal of “Pharmaceuticals”, a peer-reviewed scientific journal published by the Multidisciplinary Digital Publishing Institute, Basel, Switzerland. According to the Journal Citation Report, it is a Q1 rank journal with an impact factor of 6.00.
In this project, IUB-Pharmacology lab, Assistant Professor, Dr. Ansari collaborated with Dr. Murtaza M. Tambuwala and Dr. Hamid A. Bakshi, School of Pharmacy and Pharmaceutical Sciences, Institute of Biomedical Sciences, Ulster University, Coleraine, UK, and Dr. Faruck L. Hakkim, The Hormel Institute, University of Minnesota, Austin, USA. Dr. Murtaza Tambuwala and Dr. Faruck L. Luckman contributed on Introduction whereas, Dr. Ansari and Dr. Hamid A. Bakshi reviewed on Merits and Demerits of Colon Drug Delivery Systems. This study highlights several drug delivery systems used to modulate the microbiota and improve colon-targeted drug delivery. The prevalence of colon-associated diseases has increased significantly over the past several decades, as evidenced by accumulated literature on conditions such as Crohn’s disease, irritable bowel syndrome, colorectal cancer, and ulcerative colitis. Developing therapeutics for these diseases is challenging due to physiological barriers of the colon, systemic side effects, and the intestinal environment. Therefore, in a search for novel methods to overcome some of these problems, researchers discovered that microbial metabolism by gut microbiota offers a potential method for targeted drug delivery. This technology will be important in developing a new generation of therapies which harness the metabolism of the human gut microflora.
This article consist of various literature review by considering the current scenario of drug delivery method for colon diseases in the world. The endeavour was made possible by the dedication of Dr. Ansari, Assistant Professor, Department of Pharmacy in collaboration with overseas scientist from Ulster University, UK and University of Minnesota, USA.
The research in this direction will open a novel window of opportunity to exploit gut enzymes and microflora for effective drug delivery in various colon-related diseases such as Crohn’s disease, irritable bowel syndrome, colorectal cancer, and ulcerative colitis. This prestigious literature review demonstrates the IUB-PL, Department of Pharmacy’s enthusiastic commitment to high-quality research and contributing towards health sciences in some extent.