Dr. Prawej Ansari published an article via Oxford University Press in the high-impact journal in collaboration with Ulster University and University of Strathclyde, UK
Dr. Prawej Ansari, Assistant Professor, Department of Pharmacy, School of Pharmacy and Public Health has published a journal paper on the 1st of March 2022, titled “In vitro and in vivo antihyperglycemic activity of the ethanol extract of Heritiera fomes bark and characterization of pharmacologically active phytomolecules” in the “Journal of Pharmacy and Pharmacology”, a peer-reviewed scientific journal published by the Oxford University Press, Oxford, UK. According to the Journal Citation Report, it is a Q1 rank journal with an impact factor of 4.00.
In this project, IUB-Pharmacology lab, Assistant Professor, Dr. Ansari collaborated with Dr. Yasser Abdel-Wahab School of Biomedical Sciences, Ulster University, Coleraine, UK, and Dr. Veronique Seidel, University of Strathclyde, UK. This study highlights the antidiabetic insulinotropic activities of Heritiera fomes bark together with Pharmacologically active phytoconstituents. The research team member from IUB-PL performed the in vivo studies on streptozotocin (STZ)- induced type-2 diabetic animals for this project whereas, DRG was the leading group in this project specially on the experiments including in vitro and, isolation and characterization of phytomolecules.
The current findings indicated that ethanol extract of Heritiera fomes (EEHF) significantly increases insulin release with stimulatory effects comparable to 1 µM glucagon-like peptide 1, which somewhat reduces by diazoxide, verapamil and calcium-free conditions. Insulin release is further stimulated by tolbutamide, isobutyl methylxanthine and KCl. EEHF induces membrane depolarization and increases intracellular Ca2+ levels. EEHF enhances glucose uptake in 3T3L1 cells and decreases protein glycation. EEHF significantly inhibits postprandial hyperglycaemia following sucrose loading and inversely elevates unabsorbed sucrose concentration in the gut. It suppresses glucose absorption during in situ gut perfusion. Furthermore, EEHF improves glucose tolerance, plasma insulin and gut motility, and decreases plasma dipeptidyl peptidase IV activity. Procyanidins, epicatechin and proanthocyanidins are some of the identified bioactive constituents that may involve in β-cell actions. This study provides some evidence to support the use of H. fomes as an antidiabetic traditional remedy.
The research article has involved laboratory-based work by taking into account the current rapidly growing scenario of diabetes patients all over the world. The endeavour was made possible by Dr. Prawej Ansari, Assistant Professor, Department of Pharmacy, and his consistent efforts to provide world-class scientific research discoveries from IUB. This distinguished publication demonstrates the IUB-PL as well as Department of Pharmacy’s passionate dedication to high-quality research and contributing to health sciences to some level.
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